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The habenula has notably high levels of MOR (medial habenula) [44] and also expresses KOR (lateral habenula) [45], is implicated in aversive states [46] including NPW [20], and modulates DA release [47, 48]

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(source: sec.gov) January 2026 : Novo Nordisk announced the broad availability of the Wegovy pill across America

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Several oral peptide drugs have already been approved for the management of chronic diseases, including RYBELSUS (Semaglutide) for type 2 diabetes, DAYBUE (Trofinetide) for Rett syndrome, LUPKYNIS (Voclosporin) for lupus nephritis, and TRULANCE (Plecanatide) for chronic idiopathic constipation and irritable bowel syndrome with constipation