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Mechanism of action of GLP-1 receptor agonists GLP-1 is a hormone released by the small intestine in response to food intake

Administration of 300 mg/kg of APAP led to 100% mortality within 6 h, but 1,000 mg/kg of natsumikan extract and silymarin prolonged survival rates to 33.3% and 50.0%, respectively

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Liraglutide (0.2 mg/kg) was intraperitoneally injected 45 min before performing insulin, glucose, and pyruvate tolerance tests (ITT, GTT and PTT respectively)