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The intranasal formulations are not approved to treat acute B12 deficiency

Use Clinical Gloves: After washing your hands, wear clinical gloves to handle the materials

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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

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Different antibody isotypes have different flexibilities that might affect how the two Fab arms of an antibody interact with virion surface proteins, both in terms of intrinsic affinity and avidity through bivalent binding