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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability

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Paraesthesia (pins and needles) in the hands and feet often improves within two to four weeks, though complete resolution may take several months

Nature 2021;594, 100-105, doi:10.1038/s41586-021-03547-7

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