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The hallmark pathologies in AD are the accumulation of amyloid-beta (A) plaques and tau tangles in the brain, leading to neuronal loss and brain atrophy [3, 4]

Providing accurate, evidence-based information is essential [12]

We searched using the keywords: ("Methylenetetrahydrofolate reductase" OR MTHFR) AND ("colorectal cancer" OR "colon cancer" OR "rectal cancer") AND"Genetic polymorphisms"

Brown-Joel ZO, Colleran ES, Stone MS

Funding Statement The author(s) declare that financial support was received for the research and/or publication of this article

Oxidative stress has been implicated in the majority of amyloid disorders, and recent reviews provide comprehensive overviews of its role in TTR amyloidosis [26]