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The biologic plausibility of GLP-1 receptor agonists for HS lies in their immunomodulatory and anti-inflammatory properties

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However, minor structural modifications between the hexapeptide chains yield profoundly distinct adverse effect profilesmost notably regarding ghrelin mimicry and hunger signaling

"I think there shouldn't be this panic out there in the marketplace, but this is a trend that's not going away," Baggett said

The clinical studies have demonstrated the synergistic effects of GIP and GLP-1 agonism on glucose metabolism and body weight in these unimolecular dual agonists (63, 76), marking a significant achievement in the pharmaceutical development of incretins, which will be further discussed in the next section