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Rapid weight loss associated with semaglutide may paradoxically increase gallstone formation risk, as noted in FDA prescribing information
NC Medicaid followed, removing obesity coverage effective October 1, 2025, while retaining coverage for the cardiovascular, MASH, and OSA indications
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Benefits of semaglutide in glycemic control, weight reduction, and cardiovascular risk mitigation remain well established
Semaglutide has oral versions (the Ozempic pill 1.5/4/9mg for type 2 diabetes, which reformulated and renamed Rybelsus in 2026, and the Wegovy pill 25mg for weight management) while tirzepatide is injection-only
