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For patients with obesity, significant weight loss can result in restored ovulation, more regular periods, and rebalanced estrogen, a hormone that rises with obesity and can diminish fertility

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This comparison allows patients to see why tirzepatide seems to have a more adaptable upper range, whereas semaglutide sticks to a steadier and more consistent progression

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These findings underscore the multifunctionality of GLP-1R as a therapeutic target and its involvement in various biological processes, emphasizing its role in addressing complex disease mechanisms