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The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)

Thus, is it reasonable to proceed as usual, as the guidance states

What the research keeps pointing to is meals built on three things working together: protein, soluble fiber, and healthy fats

Performance metrics If you are resistance training, track your lifts

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Side Effect Profiles The most noticeable practical difference is that dual agonists like tirzepatide tend to cause slightly more gastrointestinal side effects than pure GLP-1 agonists