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Zhang T, Xiao JG, Zhao YS, Zhang YF, Jie YQ, Shen DD, Yue CP, Huang JY, Hua YP, Zhou T

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The 5 and 3 targeting regions were independently cloned into the TOPO TA vector (Invitrogen TM ), digested and then cloned into the pL0001-digested plasmid

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