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Because bioavailability is lower, sublingual troches often require higher nominal doses compared to injectable protocols

Study population We implemented two active comparator, new user cohorts.26 The first cohort was composed of patients who started and continued on either a GLP-1 receptor agonist (dulaglutide, exenatide, liraglutide (except the 3 mg/0.5 mL formulation indicated for weight loss), lixisenatide, semaglutide) or a DPP-4 inhibitor (alogliptin, linagliptin, saxagliptin, sitagliptin, vildagliptin) for the first time between 1 January 2007 (the year these medications entered the UK market) and 31 December 2020

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A: Safety data in humans is limited