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Neill AR, Grime DW, Dawson RM

These results indicate that FGF21 plays a key role in regulating the expression of genes involved in hepatic lipid homeostasis and that activation of FGF21 activity could prove to be a significant tool in the treatment of the disrupted metabolic status in diabetic individuals

48 Taken together, elevated TMAO increases patient risk for developing atrial fibrillation, which becomes even more serious when considering the pro-thrombotic effects of TMAO, which may exacerbate the clinical manifestations of arrhythmias