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the National Key Basic Research Program of China 2018YFA0507000 (MW)

EBioMedicine, 2019;doi:10.1016/j.ebiom.2019.08.069

Mechanistically, it can dampen the pro-inflammatory response by decreasing the transcription of pro-inflammatory cytokines through direct DNA binding to Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) (Wang and He, 2022)

Tumor-associated macrophages (TAMs) are of the M2 type to induce immune inhibition, achieved by secretion of regulatory cytokines and inhibition of tumor-infiltrating Lymphocytes (TILs) (33)

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Autism is associated with a deficiency in complexes 3 and 4 of the mitochondrial respiratory chain, leading to an elevated lactate-to-pyruvate ratio