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doi: 10.1038/ncomms11624 147 KollsJ

"Over time or in high doses, [the effects] can escalate to severe liver inflammation and an increased risk of acute liver failure

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

What are the results of tretinoin after 6 weeks

While a temporary decrease in NCOA4 results in less breakdown of ferritin, leading to increased iron storage and therefore less available iron in the cell [41], long-term reduction in NCOA4 expression or function, as observed in animal studies, leads to an overload of iron and oxidative stress [42]