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A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II

Lazennec, G., Rajarathnam, K

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Salvage occurs at a lower rate in the blood compared to other tissues, where PreissHandler may even be the preferred pathway 11

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