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Genetical evidence from key studies confirms that eliminating GPX4 expression via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L

Again, glutathione peroxidase 1 (GPx-1) is a critical enzyme in the protection of vessels against atherogenesis

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FASEB J 18: 385387

It has demonstrated significant anti-cancer efficacy in both preclinical and clinical trials

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