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29 GLP-1, an endocrine hormone, is secreted by enteroendocrine L-cells located in the distal jejunum, ileum, and colon in response to nutrient ingestion and neuroendocrine stimulation

Dose-response for any indication, all proposed protocols are extrapolated from animal studies

While this inherent metabolic instability averts pathological signal overamplification and receptor desensitization under physiological circumstances, it poses a fundamental pharmacokinetic hurdle for ATPtargeted therapeutic interventions [442]

Cytosolic and mitochondrial isoforms of NADP+dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells

Zechmann et al., 2005

10.1039/c6mt00195e Metallomics