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Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

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HR = 0.90 (125)], even in those patients with previous heart failure (132134), suggesting that the increased risk with saxagliptin is not mechanistically related to the inhibition of DPP-4 per se , but the cause is still unexplained

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