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In the REDEFINE 1 phase III trial, participants lost over 20% of body weight on average over 68 weeks using the CagriSema combination (cagrilintide plus semaglutide)

That's a small study

These alternatives do not replicate tirzepatide dual agonism but allow investigation of overlapping metabolic pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Yang L, Yang J, Pan T, Zhong X

Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation