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For the behavioral experiments of SPF-Sham, ABX-Sham and ABX-SDV, mice were tested for OFT at 11 weeks of age, EPM at 12 weeks of age, and motor function test (wire hanging test, ledge test, and hindlimb clasping test) at 13 weeks of age

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Because of the risk of addiction or abuse, such stimulant drugs are "controlled substances," which means they need a special type of prescription

1,3,5 Despite these observations, konjac supplementation alone is not sufficient to induce significant weight loss, as dietary patterns, gut microbiota composition, and adherence to supplementation protocols contribute to variable individual responses