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In some people, particularly older adults or those with limited protein intake, both glycine and cysteine availability may constrain glutathione synthesis

High homocysteine not responding to methylfolate : A 2023 RCT found people with MTHFR C677T had better homocysteine balance with folinic acid than methylfolate. Who Should Avoid Folinic Acid: MTHFS Variants The MTHFS enzyme converts folinic acid into other usable folate forms