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This results in cell cycle arrest in T & B cells, which inhibits T-cell proliferation and reduces the production of autoantibodies by B cells (Furst et al, 2012) Sulfasalazine mechanism : inhibits the release of inflammatory cytokines (Furst et al, 2012) Biologic DMARDs Biologics are the newest class of drugs for treating RA, and act by

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Human T H 17 cells engage gasdermin E pores to release IL-1 on NLRP3 inflammasome activation

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