GLP-1 works by signaling the brain that the body is full, even with smaller portions of food, and by slowing the emptying of the stomach
The role of c-Jun phosphorylation in EpRE activation of phase II genes
The body may adapt to the drug over time, so these side effects may become more bearable or go away completely
This idea is further supported as melatonin lowered the contents of secondary metabolites by suppressing genes involved in anthocyanin biosynthesis and MYB transcription factors which are associated with reddening index, anthocyanin content and cyanidin-3-O-glucoside (Xu et al., 2022)
doi:10.1016/j.ymgme.2006.01.010
Exenatide activated eNOS and NO production in endothelial cells, induced dose-dependent vasorelaxation, and mitigated high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo, effects which were reduced by AMPK (AMP-activated protein kinase) inhibition [86]