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Loren Pickart identified over 4,000 genes influenced by GHK-Cu, with 31% upregulated and 35% downregulated

These medications reduce inflammation and fibrosis, which helps protect the kidneys

In selected cases meeting NICE criteria for obesity pharmacotherapy (e.g., semaglutide 2.4mg/Wegovy with BMI 35 kg/m with comorbidities or 30 kg/m with weight-related comorbidities, prescribed through specialist weight management services) or bariatric surgery, these interventions may be considered, with specialist input to ensure safe implementation alongside lymphoedema management strategies

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