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Notably, E2-treatment (in the absence of LPS) also quenched the basal level of NO and Kyn level in comparison to the control cells (Figs

It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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