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In particular, signals from the gut can activate specialized neurons of the arcuate nucleus (ARC) that regulate energy and glucose homeostasis, including agouti-related peptide/neuropeptide Y orexigenic neurons and pro-opiomelanocortin/cocaine and amphetamine-regulated transcript anorexigenic neurons 22,33,34,35

doi: 10.1111/acel.2016.15.issue-1 115 FontanaLWeissEPVillarealDTKleinSHolloszyJO

Some older researchers report dramatic results at doses that produce subtle effects in younger users