One practical strategy many prescribers recommend is taking bupropion first thing in the morning on an empty stomach, 30 to 60 minutes before eating
On the upside: Early research suggests they may improve brain insulin signaling, lower inflammation, protect blood vessels, and even encourage new neuron growth all potentially protective against Alzheimers
In fact, they were approved for treatment of type 2 diabetes in 2005
That alone is a big monster in the room
Phentermine causes stimulant effects: insomnia, palpitations, anxiety, and dry mouth, plus cardiovascular strain
As the authors point out, long-term proton pump inhibitor use is connected to serious side effects and increases the risk of some other potentially serious conditions such as Clostridium difficile associated diarrhea, osteoporosis, and vitamin or electrolyte malabsorption