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First, 100 M PAR was blanked with the appropriate agent at 492 nm, after which MT2 was added, and the reaction was monitored for 60 min (Fig

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Internalization separates the ligand from the receptor via the acidic endosomal route, where caveolin- or clathrin-dependent mechanisms may be used for internalization ( 4 The role of the IGF family in carcinogenesis The IGF family plays a critical role in various cellular processes such as proliferation, differentiation, and apoptosis ( Figure 1 )

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Upon reaction with GSH in cancer cells, dissociation of MOFs will occur, and the released drugs exert chemotherapy efficacy (Wang et al