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However, the expression of Klotho and autophagic activity were remarkably suppressed in DKD mice and renal proximal tubule cells exposed to high glucose ( Autophagy dysregulation is involved in the pathophysiology of DKD by increasing ROS production, mediating inflammatory responses and inducing renal cell damage and apoptosis ( 3.8.3 Pyroptosis Pyroptosis is a novel type of PCD, distinct from apoptosis and autophagy

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