Treatment of mice with NAC NAC (Sigma, A8199) was made fresh for each experiment in 0.9% saline at 20 or 30 mg/ml
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Tetracycline inhibited the production of IL-1 and IL-18 by alveolar leukocytes in a dose-dependent manner
On the other hand, Sesamin and Quercitrin showed a LD50 value of 1500 mg/kg and 5000 mg/kg respectively, which lied in the range of LD50 values exhibited by 4-Hydroxy PBN, NXY-059, NAC and PBN suggesting its potent role as an anti-oxidant along with a good MD simulation and Docking results
Next comes the only slightly uncomfortable moment inserting the catheter