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In studies of Ras-driven carcinogenesis in RDEB-severe generalized keratinocytes, retention of the amino-terminal NC1, the first noncollagenous fragment of type VII collagen, is tumorigenic in mice.[151] This retained sequence may mediate tumor-stroma interactions that promote carcinogenesis

Copper peptides are naturally occurring complexes formed when small protein fragments, known as peptides, bind with copper ions in their divalent state

They stimulate insulin release

Contraception is required during treatment with these agents due to potential fetal harm

Dosage 1 capsule twice daily

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