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While most of the canonical IGF-IR signaling processes are conducted in the cytosol, IGF-IR may translocate to the nuclei and then regulate gene transcription, which represents a non-canonical function of IGF-IR
A governance framework that formalizes the relationship between these domains can enable more cohesive policies, facilitating the creation of mixed-use developments, transit-oriented projects, and pedestrian-friendly spaces
FIGURE 3 Moreover, a patent application has been filed by Magnani et al
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Treatment strategies may differ based on disease extent and severity, depicting the importance of an accurate diagnosis for tailoring an appropriate management plan [49, 50]
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