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Li N, Han Z, Li L, Zhang B, Liu Z, Li J

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The optimal administration window is 3060 minutes before sleep onset, on an empty stomach (minimum three hours post-meal)

However, research has found evidence that birth control pills can lead to lower levels of vitamin B6 [25]

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A later review described DSIP as a still unresolved riddle, emphasizing that the sleep-factor hypothesis, receptor biology, and gene-level interpretation remain poorly documented [2]