S-Adenosylmetliionine and methylation
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In the ATTAIN-1 Phase 3 trial, patients taking the highest daily dose lost an average of approximately 11% of their body weight over 72 weeks
Lancet 402: 529544, 2023
The atomic coordinates and electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession codes: 7FIY (tirzepatideGIPRG s complex), 7VAB (non-acylated tirzepatideGIPRG s complex), 7FIM (tirzepatideGLP-1RG s complex), 7VBI (non-acylated tirzepatideGLP-1RG s complex), 7FIN (peptide 20GIPRG s complex), 7VBH (peptide 20GLP-1RG s complex) and 7V35 (peptide 20GCGRG s complex), as well as Electron Microscopy Data Bank (EMDB) under accession codes: EMD-31606 (tirzepatideGIPRG s complex), EMD-31836 (non-acylated tirzepatideGIPRG s complex), EMD-31603 (tirzepatideGLP-1RG s complex), EMD-31880 (non-acylated tirzepatideGLP-1RG s complex), EMD-31604 (peptide 20GIPRG s complex), EMD-31879 (peptide 20GLP-1RG s complex) and EMD-31676 (peptide 20GCGRG s complex), respectively
