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While this could be due to the fat content of fish oil, the ingested oil floating on top of the stomach contents likely contributes to this side effect ( Splitting your fish oil into two smaller doses and taking it in the morning and at night is an effective strategy that can help prevent acid reflux and indigestion ( Summary Because most of the benefits of fish oil are associated with long-term use, you can take it at any time of day

Cyclooxygenase in normal human tissuesis COX-1 really a constitutive isoform, and COX-2 an inducible isoform