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Pancreatitis history is also a standard contraindication under clinical evaluation protocols

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In clinical studies targeting obesity, particularly in the phase 3 trials based on the SURPASS program, tirzepatide demonstrated outstanding weight reduction benefits, with some patients achieving a weight loss of up to 22.5%

J Neurosci 23:33943406 Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005) Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo

The fact these medicines are being produced in large numbers, when compounded medicines are meant to be provided for individuals only, is another area the regulator is worried about