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Quick Answer: Guidelines recommend considering GLP-1 receptor agonists for weight regain after bariatric surgery when BMI remains 27 kg/m with comorbidities or 30 kg/m, lifestyle modifications are insufficient, and no anatomical complications require surgical revision

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Regional Studies ACHIEVE-J (NCT06010004) evaluates orforglipron specifically in Japanese patients with type 2 diabetes, addressing potential population-specific differences in efficacy, safety, and dosing requirements that are important for regulatory submission in Japan

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2023 Dec;12(4):45373