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OW semaglutide significantly reduced mean HbA1c and body weight compared to OD empagliflozin, suggesting superior efficacy when added to metformin monotherapy

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Likewise, reduced dehydroascorbic acid (an oxidized form of ascorbic acid) combined with increased threonic acid (a major breakdown product of ascorbic acid) levels in the CSF indicates a change in oxidative stress response: dehydroascorbic acid has neuroprotective effects against free radicals in the brain, while threonic acid may interfere with the metabolism of ascorbic acid [137]