The extent of weight loss likely also reflects the potency of anti-inflammatory effect, and biomarkers indicative of reduced inflammation have been shown to precede wight loss in multiple trials of this drug class
PMID: 11018622 Levine N, Dorr RT
In contrast, another group demonstrated that peripheral administration of either liraglutide or Ex-4 induced a reduction in food intake in both control rats as well as rats that have had subdiaphragmatic vagal deafferentation (Kanoski et al., 2011)
The trial also documented a reduction in WOMAC pain scores by up to 75.8%, improvements in non-HDL cholesterol, and reductions in systolic blood pressure
Naderi, S., Acar, F., Mertol, T
Data have shown that an icv injection of GLP-1 diminished the level of 5-HT in the hypothalamus of SpragueDawley rats compared with control animals