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As changes in heat sensitivity are dependent on TRPV1 activity, we sought to determine whether intraplantar injection of 10 g of GLP-1(736) modulates spontaneous pain behavior induced by the TRPV1 agonist CAP in mice

Reduced Side Effects : Some patients experience nausea or other side effects with full-dose GLP-1 therapy

It can also cause acid reflux or irritate the vagus nerve, both of which are known to trigger the involuntary contraction of the diaphragm that we recognize as a hiccup