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Nutrients (2020) 12(8):2464

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Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats

(AAOS Orthopaedic Sports Medicine) screened 544 peer-reviewed articles and identified 36 qualifying studies: 35 preclinical (rodent and dog models) and exactly 1 human trial

(2017) Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

So, I think that sort of forms the foundation there