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In SURMOUNT 1, tirzepatide induced a mean BW reduction of 15.0%, 19.5% and 20.9% with 5 mg, 10 mg and 15 mg, respectively compared to 3.1% obtained with placebo at 72 weeks 34
The peptide was prepared as a 5 mg/ml stock solution in sterile water, then further diluted to a final concentration of 20 mol/L in tank water
134 AEs were common (up to 82% of patients but with a similar proportion of placebo and treatment group patients reporting AEs in the RCT) and generally not serious (e.g., short-term sedation, weakness)
Establish long-term eating patterns
Chewable or gummy vitamins are more susceptible to moisture than capsules or tablets
However, nasal spray's rapid onset may benefit acute injuries, while oral administration might better support chronic gastrointestinal issues through direct tissue contact
