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doi: 10.1038/sj.onc.1202237

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-MSH activates melanocortin receptors and: Reduces appetite Increases satiety Inhibits NPY/AgRP Neurons NPY = Neuropeptide Y AgRP = Agouti-Related Peptide These neurons normally: Increase hunger Promote food seeking Amylin suppresses their activity

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In doing so, they also slow foods pace through your body