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Endocrine Research, 45 (3), 203-215

FIGURE 2 Role of NRF2 in neurodegenerative diseases Oxidative stress, neuroinflammation, and mitochondrial dysfunction are prevalent characteristics of the aging brain and research indicates that the expression of NRF2 and its downstream genes declines with age (Schmidlin et al., 2019)

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Defense-related genes encoding osmotin, PR-1b, chitinase, and superoxide dismutase (SOD) enzymes were up-regulated in the transgenic lines as compared to wild-type plants