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For most people, the daily "drip-feed" of a bioavailable oral supplement is more effective for long-term skin management than occasional high-dose injections

10.1056/NEJMoa2210639 13 BhargavaP.SchnellmannR

Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches

Oxidative stress damages skin cells, accelerates collagen breakdown and contributes to a dull, tired appearance particularly in patients with chronic UV exposure, frequent travel and disrupted sleep

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Allantoin has been associated with mitochondrial membrane potential (MMP), and suppression of mitophagy and ROS levels, contributing to improved ovarian function in CTX-induced POI models (Wang et al., 2023c)