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Regardless of mechanism, improved comfort often accompanies early protocol phases

doi: 10.3389/fpsyg.2025.1641693 Received 06 June 2025 Accepted 19 August 2025 Published 09 September 2025 Volume 16 - 2025 Edited by Mark Antoniou, Western Sydney University, Australia Reviewed by Alexandra Wolf, RIKEN Center for Advanced Intelligence Project (AIP), Japan Lifeng Tang, Ningbo Rehabilitation Hospital, China Updates Copyright 2025 Maggio, Maione, Cotelli, Bonasera, Corallo, Pistorino, Luca, Marra, Quartarone, Nicoletti and Calabr

4.2 Limitations This meta-analysis has several limitations

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Less shedding and visibly thicker hair

A landmark trial found once-weekly semaglutide produced significant weight reduction in adults with obesity