Research Design and Methods Study Design This randomized, multicenter, double-blind, placebo-controlled, parallel-group phase 2 trial (clinical trial reg
Science 312 , 18821883 (2006)
A lot of the studies: Are small Have a high risk for bias (poor reporting/inconsistency/blinding/etc) Show mixed results (heterogeneity) Often the studies arent even looking at the same thing: One study might look at PCOS patients, another at endometriosis patients Another might use 800 ug of folate instead of 400 ug Some might combine different supplements instead of just one So its hard to make strong conclusions
Kidney function is another important consideration
However, it may increase skin sensitivity to sunlight, so it's important to use sun protection while using products containing Arbutin
Helps to improve liver function