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only one study had a follow-up greater than 1 year

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What I am suggesting is that there is a strong theoretical basis for why these medications might help a subset of patientsspecifically those whose symptoms map strongly onto vagal inflammation: dizziness breathlessness or air hunger heart-rate instability nausea loss of appetite gut dysmotility temperature intolerance sudden vagal surges abnormal fatigue patterns These are exactly the symptoms consistent with nodose ganglion inflammation, and this is the group most likely to benefit