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Data availability All RNA-seq data have been deposited in the GEO and are accessible through GEO Series accession numbers GSE272456 (HCT116) and 810 GSE272391 (AKP organoids) or at RNA-seq data of the clinical cohort have previously been deposited at GSE103479 (ref

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Moderate alcohol consumption, defined as up to one drink per day for women and up to two drinks per day for men, is generally considered acceptable for most patients, though individual tolerance and circumstances should be considered

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