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Ann Surg 221(3):220235 Lowenstein C, Dinerman J, Snyder S (1994) Nitric oxide: a physiologic messenger

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Over the past few years, recognition has grown of their transformational potential for the more than one billion people living with obesity and over 800 million with diabetes globally.12 However, appreciation of the risks is critical to inform evidence based discussions

It has been demonstrated that continuous GLP-1R stimulation results in rapid tachyphylaxis to the gastric slowing effects of GLP-1 but not the pancreatic effects, however with intermittent stimulation of the GLP-1R with shorter-acting agonist gastric slowing is maintained [54]

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